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Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Conduction System of the Heart01:19

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Conduction System of the Heart01:20

Conduction System of the Heart

The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Articles linked to this work by shared authors, journal, and citation graph.

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Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism.

American journal of physiology. Heart and circulatory physiology·2001
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[Chronic heart failure--suggestion to a management program].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1999
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Left ventricular dysfunction following rewarming from experimental hypothermia.

Journal of applied physiology (Bethesda, Md. : 1985)·1998
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Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans.

The American journal of clinical nutrition·1998
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[Calcium channel blockers in heart failure].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1997
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[Treatment of heart failure with beta-blockaders].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1997

Related Experiment Video

Updated: Jun 22, 2026

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
09:34

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Multilevel disease of the conduction system.

K Rasmussen, E S Myhre, P Gunnes

    European Heart Journal
    |February 1, 1983
    PubMed
    Summary

    Conduction system disease often affects multiple heart levels simultaneously. Multilevel defects are linked to more severe symptoms and generalized heart conditions.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Cardiac Electrophysiology

    Background:

    • Conduction system disease affecting multiple cardiac levels is not well-documented.
    • Understanding the distribution and incidence of these multilevel defects is crucial for patient management.

    Purpose of the Study:

    • To analyze the incidence and distribution of conduction system disease across multiple levels.
    • To characterize patients with single-level versus multilevel conduction system disease.

    Main Methods:

    • Retrospective analysis of patients diagnosed with conduction disease and complete electrophysiological studies.
    • Classification of patients based on sinus node disease and proximal/distal atrioventricular disease.
    • Inclusion of a representative patient cohort from a defined hospital population.

    More Related Videos

    Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
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    Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

    Published on: June 16, 2020

    Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
    09:20

    Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

    Published on: July 5, 2021

    Related Experiment Videos

    Last Updated: Jun 22, 2026

    Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
    09:34

    Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

    Published on: August 27, 2019

    Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
    09:35

    Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

    Published on: June 16, 2020

    Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
    09:20

    Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

    Published on: July 5, 2021

    Main Results:

    • 41% of 59 patients exhibited defects at more than one conduction system level.
    • 55% of patients with sinus node disease also had atrioventricular disease; 42% of atrioventricular disease patients showed sinus node failure.
    • Multilevel disease patients were older, had more severe symptoms, and higher rates of generalized heart disease.

    Conclusions:

    • Conduction system disease frequently involves multiple levels, suggesting a diffuse underlying process.
    • Multilevel involvement is associated with poorer clinical outcomes and comorbidities.
    • Findings support the concept of conduction system disease as a progressive, systemic condition.