[Clinical study of the pharmacodynamics of drugs used for premedication]

The use of premedication varieties in surgical treatment of 52 patients with heart diseases of varying etiology has demonstrated that the most effective were antihypoxic agents (sodium hydroxybutyrate), substances reducing myocardial requirement of oxygen (cardiac glycosides) and decreasing load of the heart (anapriline, verapamil), normalizing myocardial function (a polarizing mixture, cardiac glycosides), antithrombotic substances (heparin), antihistamine and antishock agents (diphenhydramine, pipolphen, morphine, promedol, prednisolone, neuroleptics, tranquilizers), and substances that enhance the neutralizing liver function (vitamins B and C). Drug correction of the functional and biochemical indicators should be strictly individualized with regard to the patient's age, type of pathology, and the scope of the coming surgical intervention.