Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in corneal DC-potentials associated with changes in pupillary diameter.

D Bracher, R Bütikofer, F Garrett

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Top ten research priorities for spinal cord injury: the methodology and results of a British priority setting partnership.

    Spinal cord·2015
    Same author

    Polymerase chain reaction comparison of the gene for strictosidine synthase from ten Rauvolfia species.

    Plant cell reports·2013
    Same author

    Effectiveness of a multi-disciplinary family-based programme for treating childhood obesity (the Family Project).

    European journal of clinical nutrition·2011
    Same author

    Experience with contact therapy.

    Radiologia clinica·2010
    Same author

    The rotational radiation of the esophageal carcinoma; therapeutic experience in 38 cases.

    Radiologia clinica·2010
    Same author

    Comparison of codes assessing galactic cosmic radiation exposure of aircraft crew.

    Radiation protection dosimetry·2009
    Same journal

    Postoperative rotational stability of the toric intraocular lens in phacovitrectomy with and without gas tamponade.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    Same journal

    Surgical management of vitreoretinal complications in X-linked retinoschisis: long-term outcomes in a pediatric population.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    Same journal

    Impact of image enhancement on grading agreement of plus disease features in retinopathy of prematurity.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    Same journal

    Association between angiogenic features and responsiveness to faricimab in treatment-naïve neovascular age-related macular degeneration with OCT angiography.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    Same journal

    Switching to aflibercept 8 mg in neovascular age-related macular degeneration: real-world outcomes according to switch indication.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    Same journal

    Correction of aphakia using biometry-based contact lens calculation in pediatric cataract extraction: introducing the aphakic contact lens formula.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
    See all related articles

    This study investigated pupillary light reflexes and electroretinograms, identifying distinct electrical potentials (cu-wave and mu-wave) linked to sphincter pupillae depolarization and pigment epithelium changes during pupil constriction.

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Physiology

    Background:

    • The pupillary light reflex is crucial for visual function.
    • Understanding the electrophysiological correlates of pupillary responses is essential.

    Purpose of the Study:

    • To investigate the electrophysiological signals associated with pupillary constriction.
    • To differentiate the origins of corneal-negative (mu-wave) and corneal-positive (cu-wave) potentials during light stimulation.

    Main Methods:

    • Monocular stimulation with light-emitting diodes (7.5–1,800 cd/m2).
    • Simultaneous recording of the DC-electroretinogram and pupillary movements.
    • Topical application of autonomic drugs (parasympatholytics, parasympathomimetics).
    • Optional recording of visual evoked potential and periorbicular muscle activity.

    Related Experiment Videos

    Main Results:

    • A corneal-positive potential (cu-wave) coincident with pupillary constriction was observed in eyes with pre-dilated pupils.
    • A corneal-negative deflection (mu-wave) dominated when pupils constricted beyond a critical point.
    • Both cu-wave and mu-wave were abolished by parasympatholytic or parasympathomimetic drugs.

    Conclusions:

    • The cu-wave is associated with sphincter pupillae depolarization during pupillary constriction.
    • The mu-wave may arise from altered potential distribution between the pigment epithelium and surrounding tissues post-critical constriction.
    • Autonomic drugs significantly modulate these pupillary electrophysiological responses.