Family occurrence and hla system in tumoral calcinosis

A 35-year-old patient, from a ten sibling family, was eight years old at the first presentation of tumoral calcinosis. Since then, in spite of several surgical excisions, the masses have increased in number and size are to be found in various para-articular areas. One brother and one sister of the patient, of 39 and 45 years respectively, had also had tumoral calcinosis, but recovered completely, on surgical removal of the masses. The HLA system studies carried out in the siblings revealed the HLA A10 BW16 haplotype in nine of them, including the three patients. If confirmed in other cases, our data might indicate that tumoral calcinosis is a disease associated with the HLA system.