[Maternal hemoglobin AIc (HbAIc) and diabetic pregnancy (author's transl)]

Third trimester HbAIc was determined in 57 pregnant women according to the TBA-reaction, first discribed by Flückiger and Winterhalter (1976). Simultaneously oral glucose tolerance tests (GTT) were performed in 52 patients; in 5 insulin dependent diabetic women dayly blood sugar profiles 2 to 5 times per week were done throughout the third trimester. HbAIc, when expressed as per cent of total hemoglobin, was 6.14 +/- 0.56% (m +/- SD) in women with normal GTT (n = 40) and found to be significantly (p less than 0,001) elevated in 7 women with abnormal GTT (7.54 +/- 0.61%; m +/- SD) and in the 5 women with insulin dependent diabetes (7.59 +/- 0.92%; m +/- SD). In patients with abnormal and boarderline GTT a linear relation between HbAIc and mean blood sugar, as determined from individually summarized 60 and 120 minutes GTT values, was observed. Insulin dependent diabetic women with higher mean blood sugar (as calculated from the total profile values throughout 4 weeks prior to HbAIc determination) showed a tendency towards higher HbAIc values.