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Allergic Aspergillus sinusitis: a newly recognized form of sinusitis
The Journal of Allergy and Clinical Immunology
|July 1, 1983
Summary
A new form of chronic sinusitis, termed allergic Aspergillus sinusitis, affects young adults with asthma and nasal polyps. It involves fungal elements and eosinophils in the sinuses, distinct from lung-related allergic conditions.
Area of Science:
- Otolaryngology
- Allergy and Immunology
- Pathology
Background:
- Chronic sinusitis is a common condition with various underlying causes.
- Allergic bronchopulmonary aspergillosis (ABPA) is a lung disease associated with Aspergillus hypersensitivity.
- A distinct clinicopathologic entity affecting the paranasal sinuses is proposed.
Purpose of the Study:
- To describe the clinical and pathologic features of a newly recognized form of chronic sinusitis.
- To differentiate this condition from other sinonasal diseases and allergic lung conditions.
- To discuss therapeutic implications and potential relationships with allergic lung diseases.
Main Methods:
- Case series review of seven patients with chronic sinusitis.
- Clinical and radiographic assessment.
- Histopathologic examination of resected sinus tissue.
Main Results:
- Patients were typically young adults with a history of asthma and chronic nasal polyps.
- Radiographic findings included opacification of multiple sinuses.
- Histology revealed mucinous material with eosinophils, Charcot-Leyden crystals, and fungal hyphae.
Conclusions:
- The findings suggest a distinct clinicopathologic entity: allergic Aspergillus sinusitis.
- This condition shares features with ABPA but is localized to the paranasal sinuses.
- Further research into therapy and its relation to allergic lung diseases is warranted.
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