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Related Experiment Videos

Anticomplementary activity in multiple sclerosis.

B Ryberg

    Journal of the Neurological Sciences
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Anticomplementary activity (ACA) in multiple sclerosis (MS) patients showed significant changes in unheated sera, potentially correlating with clinical exacerbations. This heat-labile activity is unlikely to be immune complexes.

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    Area of Science:

    • Immunology
    • Clinical Chemistry

    Background:

    • Anticomplementary activity (ACA) is frequently observed in serological assays.
    • ACA is often interpreted as indicative of circulating immune complexes and used clinically as such.

    Purpose of the Study:

    • To investigate anticomplementary activity (ACA) in multiple sclerosis (MS) patients.
    • To determine if ACA correlates with clinical disease activity in MS.

    Main Methods:

    • Longitudinal study of 35 MS patients over 5 years.
    • Assay of ACA in heated and unheated sera and heated cerebrospinal fluid (CSF).
    • Analysis of ACA heat lability and binding to human IgG immunosorbent.

    Main Results:

    • Persistent or transitory low-titer ACA was found in some MS patients, with limited correlation to clinical events.

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  • Marked ACA in unheated sera was more frequent in MS patients than controls.
  • Dramatic ACA fluctuations were observed in 15 MS patient sequences, sometimes correlating with clinical exacerbations.
  • This marked ACA was heat-labile and did not bind to IgG immunosorbents, suggesting it is not IgG aggregates or immune complexes.

    • Conclusions:

    • A heat-labile anticomplementary activity, distinct from immune complexes, is observed in MS patients.
    • This ACA may fluctuate and potentially correlate with clinical exacerbations in multiple sclerosis.