[Study on distribution to oral tissues of long acting amoxicillin]

The distribution of L-AMPC, a newly developed long acting amoxicillin granules, was studied in oral tissues using New Zealand White rabbits. The antibiotic was dosed at 20 mg/kg and the tissue concentrations were measured in the tongue, gingiva, submaxillary gland, cervical lymph node and the parotid gland. Amoxicillin concentrations in liver and kidney were monitored for reference and urinary recovery was measured over 5 hours. All tissue concentrations were both high and persistent whereas amoxicillin concentrations in kidney and liver were high and low, respectively, the observation consistent with the published data for amoxicillin.