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Decrease of urinary taurine in essential hypertension.

N Kohashi, R Katori

    Japanese Heart Journal
    |January 1, 1983
    PubMed
    Summary
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    Essential hypertension is linked to lower urinary taurine excretion, suggesting a taurine deficiency contributes to high blood pressure and atherogenesis. This study measured taurine levels in plasma, blood, and urine of hypertensive patients and normal individuals.

    Area of Science:

    • Cardiology
    • Nephrology
    • Biochemistry

    Background:

    • Essential hypertension is a complex condition with multifactorial causes.
    • Taurine, an amino acid, plays various physiological roles, including cardiovascular regulation.
    • The relationship between taurine metabolism and hypertension pathogenesis requires further elucidation.

    Purpose of the Study:

    • To investigate the association between taurine levels and essential hypertension.
    • To determine if taurine deficiency is implicated in the development of hypertension and related cardiovascular issues.

    Main Methods:

    • Measured taurine content in plasma, whole blood, and urine of 18 healthy individuals and 79 hypertensive patients (untreated, treated, and labile).
    • Analyzed urinary taurine excretion, taurine clearance, and taurine/creatinine ratio.

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  • Correlated blood pressure, creatinine clearance, serum HDL cholesterol, and cardiac index with urinary taurine excretion.

    • Main Results:

    • No significant differences in plasma or whole blood taurine between normals and essential hypertensives.
    • Significantly lower urinary taurine excretion in untreated (708.1 +/- 57.1 mumol/day) and treated (953.6 +/- 94.3 mumol/day) essential hypertensives compared to normals (1594.0 +/- 143.7 mumol/day).
    • Markedly decreased taurine clearance and taurine/creatinine ratio in untreated essential hypertensives. Negative correlations found between blood pressure and urinary taurine excretion; positive correlations between urinary taurine excretion and HDL cholesterol and cardiac index.

    Conclusions:

    • Taurine deficiency plays a significant role in elevating blood pressure in essential hypertension.
    • Taurine deficiency may also contribute to atherogenesis.
    • Urinary taurine excretion is a potential biomarker for essential hypertension and associated cardiovascular risks.