Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catecholamine effects on frog dorsal root terminals.

G P Ryan, J C Hackman, C J Wohlberg

    Neuroscience Letters
    |March 28, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Subarachnoid hemorrhage or migraine?

    Headache·2001
    Same author

    Pentobarbital-activated Cl(-) channels in cultured adult and embryonic human DRG neurons.

    Brain research. Developmental brain research·2000
    Same author

    GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons.

    Journal of neurophysiology·1999
    Same author

    Alphaxalone activates a Cl- conductance independent of GABAA receptors in cultured embryonic human dorsal root ganglion neurons.

    Journal of neurophysiology·1999
    Same author

    On headache and the neck.

    Cephalalgia : an international journal of headache·1999
    Same author

    Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.

    British journal of pharmacology·1999
    Same journal

    Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

    Neuroscience letters·2026
    Same journal

    Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

    Neuroscience letters·2026
    Same journal

    Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

    Neuroscience letters·2026
    Same journal

    Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

    Neuroscience letters·2026
    Same journal

    Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

    Neuroscience letters·2026
    Same journal

    Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

    Neuroscience letters·2026
    See all related articles

    Catecholamines like dopamine, norepinephrine, and epinephrine influence frog spinal cord sensory input. They primarily cause hyperpolarization of afferent nerve terminals, suggesting a role in sensory processing.

    Area of Science:

    • Neuroscience
    • Neurophysiology
    • Spinal Cord Research

    Background:

    • Catecholamines are neurotransmitters with diverse roles in the central nervous system.
    • The specific effects of catecholamines on primary afferent fiber terminals in the spinal cord are not fully elucidated.

    Purpose of the Study:

    • To investigate the complex effects of dopamine, norepinephrine, and epinephrine on frog spinal cord primary afferent fiber terminals.
    • To determine the role of catecholamines in sensory input processing within the spinal cord.

    Main Methods:

    • Isolated superfused frog spinal cord preparation.
    • Application of catecholamines (dopamine, norepinephrine, epinephrine) at varying concentrations and durations.
    • Assessment of changes in primary afferent terminal membrane potential.

    Related Experiment Videos

  • Pharmacological manipulation using tetrodotoxin, Mn2+, mephenesin, and imipramine to probe response mechanisms.

    • Main Results:

    • Catecholamines induced complex effects, including slow hyperpolarization at lower concentrations (≤10 microM).
    • Depolarizations were observed with higher concentrations or prolonged application.
    • Responses were partially indirect, as indicated by reductions with tetrodotoxin, Mn2+, or mephenesin.
    • Imipramine enhanced hyperpolarizations, suggesting a role for catecholamine uptake inhibition.

    Conclusions:

    • Catecholamines modulate the excitability of primary afferent terminals in the frog spinal cord.
    • These modulatory effects, particularly hyperpolarization, suggest a role for catecholamines in regulating sensory information transmission.
    • The findings support the hypothesis that catecholamines are involved in the processing of sensory input at the spinal cord level.