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Related Experiment Videos

Variation with age of reference values for P-cobalamins.

E Nexø

    Scandinavian Journal of Haematology
    |May 1, 1983
    PubMed
    Summary

    Plasma cobalamin (vitamin B12) levels naturally decrease with age in adults. This study analyzed 279 individuals, establishing age-related reference intervals for better interpretation of vitamin B12 status.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Gerontology

    Background:

    • Cobalamin (vitamin B12) is essential for numerous physiological processes.
    • Age-related changes in nutrient levels can impact health and disease risk.
    • Understanding population-level vitamin B12 status is crucial for public health.

    Purpose of the Study:

    • To investigate the relationship between age and plasma cobalamin levels in a general population.
    • To determine age-specific reference intervals for plasma cobalamin.
    • To evaluate the appropriateness of a single reference interval for all adults.

    Main Methods:

    • Plasma samples were collected from 279 participants aged 20-80 years.
    • Cobalamin concentrations were measured using a validated assay.
    • Statistical analyses were performed to assess age-related trends and establish reference intervals.

    Main Results:

    • Plasma cobalamin concentrations showed a significant decrease with increasing age.
    • The mean cobalamin level declined across the studied age range.
    • The reference interval for plasma cobalamin broadened with age, indicating greater variability in older adults.

    Conclusions:

    • A single, universal reference interval for plasma cobalamin may not be optimal for all age groups.
    • Age-specific reference intervals could improve the accuracy of cobalamin status assessment.
    • Further research is warranted to validate age-adjusted reference ranges for clinical application.

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