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[Glomerular changes in reflux nephropathy].

J Hösli, G Keusch, J Briner

Schweizerische Medizinische Wochenschrift

|March 26, 1983

Summary

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Bilateral vesicoureteral reflux can lead to kidney damage even after surgery. Glomerulosclerosis and interstitial damage in the kidneys may cause worsening renal insufficiency.

Area of Science:

Nephrology
Pediatric Nephrology
Urology

Background:

Vesicoureteral reflux (VUR) is a common condition in children.
Surgical correction aims to prevent kidney damage and preserve renal function.
Proteinuria and progressive renal insufficiency are indicators of poor outcomes.

Observation:

Two patients with bilateral VUR experienced worsening renal insufficiency post-surgery.
Persistent proteinuria was noted in both cases.
Renal biopsy revealed interstitial damage and glomerulosclerosis.

Findings:

Segmental and focal glomerulosclerosis were observed in renal biopsies.
Interstitial damage was a prominent feature.
These histological findings suggest a link to reflux nephropathy.

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Implications:

Glomerular lesions may significantly contribute to renal function decline in reflux nephropathy.
Further research is needed to understand the pathogenesis and long-term outcomes.
This highlights the importance of monitoring renal function and histology in VUR patients.