Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous opiates mediate radiogenic behavioral change.

G A Mickley, K E Stevens, G A White

    Science (New York, N.Y.)
    |June 10, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Owners' views of canine nutrition, weight status and wellbeing and their implications for the veterinary consultation.

    The Journal of small animal practice·2022
    Same author

    Evaluation of vegetable protein in canine diets: Assessment of performance and apparent ileal amino acid digestibility using a broiler model.

    Journal of animal physiology and animal nutrition·2017
    Same author

    "Who's been a good dog?" - Owner perceptions and motivations for treat giving.

    Preventive veterinary medicine·2016
    Same author

    Rapeseed napin and cruciferin are readily digested by poultry.

    Journal of animal physiology and animal nutrition·2016
    Same author

    Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.

    Translational psychiatry·2015
    Same author

    Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

    Neuroscience·2014

    Ionizing radiation exposure in mice induced hyperactivity, mimicking morphine effects. Naloxone blocked this response, suggesting endorphins play a role in radiation-induced behavioral changes.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Radiation Biology

    Background:

    • Ionizing radiation exposure can induce significant physiological and behavioral changes in mammals.
    • Morphine, an opioid agonist, is known to cause locomotor hyperactivity.
    • Endogenous opioids (endorphins) are implicated in stress responses and pain modulation.

    Purpose of the Study:

    • To investigate the behavioral effects of ionizing radiation exposure in a mouse model.
    • To determine if radiation-induced behavioral changes are mediated by the endogenous opioid system.

    Main Methods:

    • C57BL/6J mice were exposed to ionizing radiation.
    • Locomotor activity was assessed following radiation exposure.
    • The effect of naloxone, an opioid antagonist, on radiation-induced behavior was evaluated.

    Related Experiment Videos

    Main Results:

    • Exposure to ionizing radiation resulted in stereotypical locomotor hyperactivity in mice.
    • This hyperactivity was comparable to that induced by morphine administration.
    • Naloxone administration significantly prevented the radiation-induced behavioral activation.

    Conclusions:

    • Endorphins are likely involved in mediating certain behavioral responses to ionizing radiation.
    • The endogenous opioid system may be a target for mitigating radiation-induced behavioral side effects.