Radiation effects on submandibular gland of the rat. Stereological and ultrastructural study

The chronic effect of 2000 rd (20 Gy) of X-rays locally applied to the submandibular gland of Wistar young-adult male rats, was studied by stereology, and light and electron microscopic observations. They demonstrated that degenerative changes were observed during the first months after irradiation. Atrophic processes developed from 6 months onwards. In the acinar compartment, atrophy was progressive from the first months post-irradiation up to 9 months post-irradiation. Ductal cell membranes and mitochondrial damage were clearly detected at ultrastructural level. Nuclear fragmentation and secretory granules alterations were also frequently seen in the acinar compartment.