[Mechanism of the inhibitory effect of fat on gastric secretion]

Experiments on dogs were made to demonstrate the importance of humoral factor for the inhibitory action of fat. The mechanism of the effect of fat and antidiuretic hormone on gastric secretion was found to be different. Fatty emulsion was discovered to produce an inhibitory action on gastric secretion when administered parenterally, while lipid secretion with bile to the duodenum to be of importance. The inhibitory effect of prostaglandin E2 on gastric juice secretion was studied. It has been demonstrated that this action is not removed by adrenoblockers.