[Reactive dynamics of immunologic parameters in healthy humans and in patients with rheumatoid arthritis]

Investigations of three immune components (IgG, CRP, alpha 1 sGP) in 500 patients with rheumatoid arthritis at the beginning and the end of a spa treatment lasting 4 or 6 weeks as well as in 29 healthy test persons in monthly intervals over 2 years make clear that these immune components represent biorhythmologically regulated functions which underly a different dynamics related to the initial value. By means of the so-called "cross-over-point method" the adequate conditions can be figured. In these cases under the influence of the spa therapy a significant decrease of the dispersion at the end of the significant decrease of the dispersion at the end of the cure develops for the parameters CRP and IgG. These findings as well as the typicality of the course of the empiric regression between the beginning of the cure and the end of the cure represent criteria which are of importance for the demarcation of the dependence of the initial value to a statistical a: (a-b) effect. It is shown that the pathologically reactive dynamics of the immune components can be demarcated from the biorhythmically undisturbed dynamics.