Related Experiment Videos
Pseudopsammoma bodies in meningotheliomatous meningioma. A histochemical and ultrastructural study
Abstract:
A case of meningioma arising from the right sphenoidal ridge is presented. Histologically, the tumour was composed of whorls of meningotheliomatous cells and many tumour cells containing intracellular inclusions were PAS positive, but diastase and neuraminidase resistant. The inclusions were named pseudopsammoma bodies by Kepes in 1961. The meningioma with pseudopsammoma bodies are a very rare entity and have been described in only 7 previous reports. We had an opportunity to examine one case of a meningioma with pseudopsammoma bodies. Electron microscopically, these substances were located in the intracellular spaces lined by microvilli. In earlier reports, the substances were said to be secretory products and a possibility of meningioma cell differentiation to secretory cell was postulated. Using the Concanavalin A staining method, the results of our present study strongly support this opinion.
Insights
This study presents a rare case of meningioma with pseudopsammoma bodies. Electron microscopy and Concanavalin A staining support the theory that these bodies are secretory products of meningioma cells.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Meningiomas are tumors arising from the meninges.
- Meningiomas with pseudopsammoma bodies are exceptionally rare, with few documented cases.
Observation:
- A case of meningioma originating from the right sphenoidal ridge was analyzed.
- Histological examination revealed whorls of meningotheliomatous cells with intracellular, PAS-positive, diastase- and neuraminidase-resistant inclusions, termed pseudopsammoma bodies.
Findings:
- Electron microscopy showed these pseudopsammoma bodies within intracellular spaces lined by microvilli.
- Concanavalin A staining results strongly support the hypothesis that these bodies represent secretory products, indicating meningioma cell differentiation towards secretory cells.
Implications:
- This case contributes to the understanding of rare meningioma variants.
- Findings support the secretory cell differentiation theory for meningioma with pseudopsammoma bodies.
- Further research into meningioma cell biology and potential therapeutic targets is warranted.