Aspiration does not influence interpretation of bone marrow biopsy cellularity

Area of Science:

• Hematology
• Pathology
• Medical Procedures

Background:

• Hematopoietic cellularity in bone marrow biopsy specimens has been previously linked to preaspiration alterations.
• Evaluating aspiration-induced artifacts is crucial for accurate diagnostic interpretation of bone marrow biopsies.

Purpose of the Study:

• To assess the impact of preaspiration on the evaluation of hematopoietic cellularity in bone marrow biopsy specimens.
• To determine if a one-step aspiration-biopsy technique can be safely implemented without compromising diagnostic accuracy.

Main Methods:

• Comparison of preaspirated and nonaspirated bone marrow biopsy specimens from 14 individual patients (28 specimens total).
• Evaluation of hematopoietic cellularity estimation in relation to preaspiration.

Main Results:

• Estimation of hematopoietic cellularity was not significantly disturbed by preaspiration in evaluable specimens.
• Adequate-sized biopsy specimens obtained after preaspiration maintained diagnostic interpretability.

Conclusions:

• Preaspiration immediately before bone marrow biopsy does not alter the interpretation of hematopoietic cellularity.
• A simplified one-step aspiration-biopsy technique is feasible, maintaining diagnostic accuracy and potentially improving patient tolerance.