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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Gastric carcinoma. A ten-year review
Annals of Surgery
|July 1, 1983
Summary
Despite routine fiberoptic endoscopy, most gastric cancer patients had advanced disease at diagnosis. Early surgical intervention and aggressive endoscopic investigation are crucial for improving outcomes in gastric adenocarcinoma.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Medical Diagnostics
Background:
- Gastric adenocarcinoma presents a significant challenge in diagnosis and treatment.
- The period 1970-1980 saw the introduction of fiberoptic esophagogastroduodenoscopy as a routine diagnostic tool.
- Understanding diagnostic and survival patterns in gastric cancer during this era is vital for historical and comparative analysis.
Purpose of the Study:
- To analyze treatment data and outcomes for 164 patients with gastric adenocarcinoma.
- To evaluate the impact of fiberoptic esophagogastroduodenoscopy on diagnosis.
- To assess factors influencing survival, including disease stage and lymph node status.
Main Methods:
- Retrospective analysis of 164 gastric adenocarcinoma patients treated between 1970-1980.
- Review of diagnostic methods, including fiberoptic esophagogastroduodenoscopy and laparotomy.
- Staging using the International TNM classification and analysis of survival rates based on stage, tumor location, resection extent, and lymph node status.
Main Results:
- Fiberoptic esophagogastroduodenoscopy achieved an 86% positive tissue diagnosis rate.
- Of 150 patients undergoing laparotomy, only 27% had curative resection; 58% underwent gastrectomy.
- Five-year survival was strongly correlated with disease stage (Stage I: 65%, Stage IV: 0%) and lymph node status (negative: 56%, positive: 17%).
Conclusions:
- The majority of gastric cancers were diagnosed at advanced stages, leading to poor prognoses.
- Despite improved endoscopy, outcomes for gastric adenocarcinoma remained discouraging during this period.
- Enhanced endoscopic investigation and earlier surgical intervention are recommended to improve patient survival.
