Establishment of slowly growing lung tumor cell model by aspiration of tumor cells

In male BDF1 mice, aspiration of suspended Lewis lung tumor cells at a certain concentration leads to the occurrence of lung carcinomas after 30 days. Under the chosen experimental conditions tumor incidence is about 70%. Within 20 days, animals die from this slowly growing tumor. Furthermore, the experimental conception offers a model which seems suitable for investigations into growth regulation of lung tumors.