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On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid
Archives of Toxicology
|March 1, 1983
Abstract:
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.