[Characteristics of kidney involvement in disseminated intravascular coagulation (morphogenesis of cortical...

Morphological examinations of 72 autopsy observations of the disseminated intravascular blood coagulation (DIVBC) syndrome (a combination of microthrombosis in renal glomeruli, adrenals, gastrointestinal tract and other organs with the hemorrhagic syndrome) led to a conclusion on the role of DIVBC in the formation of cortical renal necroses. All the observations presented capillary thrombosis of the renal glomeruli the extent and dissemination of which had influenced the size of cortical necroses. Cortical ischemia in early stages is manifested by nephrothelium dystrophy followed at 3-5 days by the development of necrosis of the tubules, glomeruli, and stroma. The formed cortical necroses of the kidneys (CNK) are demarkated, their healing occurs at the expense of the interstitial tissue, whose cells proliferate, and later collagen genesis is observed. Scars from CNK have been shown to contain tubules with an undifferentiated epithelium.