Factors affecting the exchange of apoproteins between human high density lipoprotein subclasses in vitro

We have presented evidence that apoproteins may exchange, in vitro, between all HDL subclasses tested, including HDL2b, HDL2a, HDL3, and HDL4. This exchange process is influenced by various factors including the concentrations of the subclasses and the presence of added apoprotein. This exchange process should be considered when designing experiments using HDL subclasses in vitro, and the importance of exchange in the in vivo situation should be a subject of further investigation.