Influence of bromocriptine on glucose-3-H3 metabolism in vivo

The dopaminergic agonist Bromocriptine has been perfused in vivo in normal Wistar rats to control its activity on Glucose-3-H3 metabolism. Bromocriptine shows a rapid influence on glucose production rate (Ra) and glucose utilization rate (Rd). Both rates increase, but since Bromocriptine effects on glucose production rate is more significant than the ones on glucose utilization, the final results is an increase in plasma glucose levels. Since glucose production rate in normal animals is practically equal to hepatic glucose output, the most logical explantation of Bromocriptine activity is the activation of glycogenosis with a rise of plasma glucose levels.