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Acute urticaria due to alcohol.

A D Ormerod, P J Holt

    The British Journal of Dermatology
    |June 1, 1983
    PubMed
    Summary

    Alcohol-induced urticaria, a skin rash, was effectively treated with sodium cromoglycate. This suggests a role for endogenous opiates and prostaglandins in alcohol allergy reactions.

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    Area of Science:

    • Immunology
    • Dermatology
    • Pharmacology

    Background:

    • Urticaria is a common skin condition characterized by itchy welts.
    • Alcohol consumption can trigger various adverse reactions in some individuals.
    • The specific mechanisms underlying alcohol-induced urticaria are not fully understood.

    Observation:

    • A case study details a patient experiencing urticaria exclusively after alcohol intake.
    • The patient's reaction was observed to be histamine-release mediated.

    Findings:

    • Indomethacin and naloxone were able to block the alcohol-induced urticarial eruption.
    • These findings suggest the involvement of endogenous opiates and prostaglandins in the reaction pathway.
    • Sodium cromoglycate provided complete and consistent blockade of the urticarial response.

    Implications:

    • This case highlights a potential therapeutic strategy for alcohol-induced urticaria.
    • Further research into the role of endogenous opiates and prostaglandins in allergic reactions is warranted.
    • Sodium cromoglycate may be a valuable treatment option for specific types of drug-induced urticaria.

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