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Altered polymorphonuclear leukocyte responses in psoriasis: chemotaxis and degranulation
The British Journal of Dermatology
|July 1, 1983
Summary
Polymorphonuclear leukocytes (PMN) from psoriasis patients show increased migration and enzyme secretion in response to immune signals. This heightened response may contribute to the inflammatory skin condition in psoriasis.
Area of Science:
- Immunology
- Dermatology
Background:
- Psoriasis is a chronic inflammatory skin disease.
- Polymorphonuclear leukocytes (PMN) play a role in inflammatory responses.
Purpose of the Study:
- To investigate the chemotactic activity and secretory function of PMN in patients with psoriasis.
- To compare PMN function in psoriasis patients versus healthy controls.
Main Methods:
- Assessed PMN migration in response to C5a and f-met-leu-phe (FMLP) in 20 psoriasis patients and 20 controls.
- Measured beta-glucuronidase release from cytochalasin B-treated PMN exposed to chemotaxins.
Main Results:
- PMN from psoriasis patients exhibited significantly increased migration towards C5a and FMLP compared to controls.
- Psoriatic PMN responded to lower concentrations of chemotaxins.
- PMN from psoriasis patients showed enhanced beta-glucuronidase secretion at lower chemotaxin concentrations.
Conclusions:
- PMN from patients with psoriasis display migratory and secretory hyper-responsiveness.
- This enhanced PMN activity may contribute to the perpetuation of psoriatic tissue reactions.