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Preoperative localization of virilizing tumors by selective venous sampling
American Journal of Obstetrics and Gynecology
|August 1, 1978
Summary
Selective venous catheterization successfully localized androgen-secreting ovarian tumors in two postmenopausal women with virilization. This technique precisely identified hormone-producing tumors, aiding surgical removal.
Area of Science:
- Endocrinology
- Gynecologic Oncology
- Diagnostic Imaging
Background:
- Virilization in postmenopausal women suggests an androgen-secreting tumor.
- Accurate localization of these rare ovarian tumors is crucial for effective treatment.
Observation:
- Two postmenopausal patients presented with virilization due to ovarian tumors.
- Selective blood sampling from ovarian and adrenal veins was performed for hormone level analysis.
- Elevated hormone levels, particularly testosterone, were detected in peripheral and ovarian venous blood.
Findings:
- The first patient had a lipid cell tumor in the left ovary, identified by increased hormone levels in the left ovarian vein.
- The second patient had a hilus cell tumor in the right ovary, indicated by markedly elevated testosterone in the right ovarian vein.
- Both tumors were successfully localized preoperatively using selective venous catheterization.
Implications:
- Selective ovarian and adrenal vein catheterization is a valuable tool for localizing androgen-secreting ovarian tumors.
- This diagnostic approach facilitates precise surgical planning and improves patient outcomes.
- Further research can refine this technique for diagnosing other hormone-secreting neoplasms.