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Chronic D-amphetamine and phencyclidine: effects on dopamine agonist and antagonist binding sites in the
Brain Research
|May 9, 1983
Abstract:
Dopamine agonist and antagonist binding to rat striatal and mesolimbic region tissue was examined in rats chronically treated with D-amphetamine or phencyclidine. In striatum, D-amphetamine produces a down-regulation of [3H]spiroperidol binding but an increase in [3H]ADTN bound (measured in the absence of ascorbate). This suggests that [3H]spiroperidol and [3H]ADTN bind to distinct, separate sites which can be independently regulated.