Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemispherectomy for seizures revisited.

T Rasmussen

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |May 1, 1983
    PubMed
    Summary

    A modified hemispherectomy, preserving key brain areas, effectively treats refractory seizures while preventing serious complications like superficial cerebral hemosiderosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-Term Complications of Appendectomy: A Systematic Review.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2018
    Same author

    A5 Peripheral blood cells contribute to HIV-1 viremia induced by romidepsin.

    Virus evolution·2017
    Same author

    P11. Differentially expressed micro-RNAs in microparticles from haemoglobin perfused placentas.

    Pregnancy hypertension·2015
    Same author

    Enterobius vermicularis and allergic conditions in Norwegian children.

    Epidemiology and infection·2013
    Same author

    HLA-DRB1, -DQA1 and -DQB1 alleles and haplotypes in first-generation Pakistani immigrants in Norway.

    Scandinavian journal of immunology·2011
    Same author

    Microwave characteristics of polymer electro-optic modulators.

    Applied optics·2010

    Area of Science:

    • Neurosurgery
    • Neurology
    • Epilepsy Surgery

    Background:

    • Hemispherectomy is effective for medically refractory epilepsy with hemiplegia.
    • Superficial cerebral hemosiderosis is a serious complication occurring years after hemispherectomy in 1/4-1/3 of patients.
    • Previous attempts to prevent hemosiderosis by preserving hemisphere portions reduced seizure control.

    Purpose of the Study:

    • To evaluate a novel surgical technique for hemispherectomy that prevents superficial cerebral hemosiderosis while maintaining seizure control.
    • To assess the efficacy of functional complete but anatomical subtotal hemispherectomy.

    Main Methods:

    • Preserving frontal and occipital poles while disconnecting them from the rest of the brain.
    • Performing a functional complete but anatomical subtotal hemispherectomy.

    Main Results:

    • The modified technique effectively prevents superficial cerebral hemosiderosis.
    • Therapeutic effectiveness for seizure reduction is retained, comparable to complete hemispherectomy.
    • Protects against associated complications like hydrocephalus and neurological deterioration.

    Conclusions:

    • Functional complete but anatomical subtotal hemispherectomy is a viable alternative to standard hemispherectomy.
    • This approach mitigates the risk of superficial cerebral hemosiderosis without compromising seizure control.
    • It offers a safer and effective surgical option for patients with medically refractory epilepsy and hemiplegia.

    Related Experiment Videos