Fluoro-substituted N-nitrosamines. 6. carcinogenicity of N-nitroso-(2,2,2-trifluoroethyl)-ethylamine in rats

N-Nitroso-(2,2,2-trifluoroethyl)ethylamine (F-3-NDEA) was tested for carcinogenic activity in male Sprague-Dawley rats at 4 dose levels. The compound was given by gavage twice weekly. Treatment related tumors were observed in all experimental groups and appropriate dose-response relations were seen. The main tumor localisations were the esophagus and the nasal cavity. F-3-NDEA therefore is carcinogenic in rats after oral administration, a biological effect to be expected since it had been shown earlier that this compound is enzymatically activated by dealkylation and is weakly mutagenic in bacterial assay systems. A change in organotropism is observed when comparing carcinogenicity of F-3-NDEA with the predominantly hepatocarcinogenic activity of parent N-nitrosodiethylamine.