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Reversible, Cushing-induced generalized dermatophyte infection.

J E Lewis

    Cutis
    |June 1, 1983
    PubMed
    Summary
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    A chronic fungal skin infection (dermatomycosis) in a patient resolved after treatment for Cushing's disease. This suggests hypercortisolism can worsen or cause persistent fungal infections.

    Area of Science:

    • Endocrinology
    • Dermatology
    • Mycology

    Background:

    • Chronic dermatophyte infections can be challenging to treat, often requiring prolonged antifungal therapy.
    • Griseofulvin is a common oral antifungal agent used for superficial fungal infections.
    • Cushing's disease, characterized by chronic hypercortisolism, can impact immune function and susceptibility to infections.

    Observation:

    • A patient presented with an extensive, chronic dermatophyte infection resistant to griseofulvin treatment.
    • The patient was diagnosed with Cushing's disease, indicating elevated cortisol levels.
    • Dermatomycosis resolution occurred spontaneously after successful management of hypercortisolism.

    Findings:

    • Successful treatment of Cushing's disease led to the clearance of a previously intractable dermatophyte infection.

    Related Experiment Videos

  • The study highlights a potential link between hypercortisolism and the persistence or severity of fungal skin infections.
  • Resolution of dermatomycosis was achieved without the need for additional antifungal agents post-cortisol correction.

    • Implications:

    • Evaluating for underlying endocrine disorders, such as Cushing's disease, may be crucial in managing refractory fungal infections.
    • Correction of hypercortisolism could be a therapeutic strategy for certain chronic or resistant dermatomycoses.
    • This case underscores the intricate relationship between the endocrine system and cutaneous immunity.