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Severe toxic reaction to tinidazole.
European Journal of Clinical Pharmacology
|January 1, 1983
Summary
A volunteer experienced an acute toxic reaction, including fainting and low blood pressure, after receiving tinidazole (FASIGYN). This adverse event was linked to complement factor C3 activation, suggesting a potential immune response to the drug.
Area of Science:
- Pharmacology
- Clinical Toxicology
- Immunology
Background:
- Pharmacokinetic studies are crucial for understanding drug behavior in the body.
- Tinidazole is an antimicrobial agent used to treat various infections.
- Adverse drug reactions can manifest in diverse and unpredictable ways.
Purpose of the Study:
- To report a case of acute toxic reaction following intravenous tinidazole administration.
- To investigate the potential mechanisms underlying the observed adverse event.
- To highlight the importance of monitoring patients during drug administration.
Main Methods:
- A single volunteer received a 1600 mg intravenous infusion of tinidazole over 80 minutes.
- Clinical observations of adverse events were recorded.
- Serum tinidazole concentrations were measured.
- Blood tests were performed, including assessment of immunoglobulin E and complement factor C3 levels.
Main Results:
- The volunteer experienced syncope (fainting) and hypotension shortly after tinidazole infusion.
- Serum tinidazole concentration was 35.4 mg/l at the onset of the event.
- Immunoglobulin E levels remained normal.
- A transient decrease in complement factor C3 concentration was observed post-infusion.
Conclusions:
- Tinidazole administration can precipitate acute toxic reactions in susceptible individuals.
- The observed reaction may involve complement system activation, indicated by the fall in C3 levels.
- Further research is warranted to elucidate the immunologic mechanisms of tinidazole-induced toxicity.