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Prolactin--thyroid interaction in Fundulus heteroclitus.

C L Brown, M H Stetson

General and Comparative Endocrinology

|May 1, 1983

Summary

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Ovine prolactin (oPRL) prevents ovine thyroid-stimulating hormone (oTSH)-induced increases in serum thyroxine (T4) in Fundulus heteroclitus. This occurs through direct effects on thyroid function, not by altering thyroid hormone clearance or deiodination.

Area of Science:

Endocrinology
Comparative Physiology
Fish Biology

Background:

Thyroid hormones regulate metabolism and growth in vertebrates.
Thyroid-stimulating hormone (TSH) stimulates thyroid hormone production.
Prolactin (PRL) is a hormone with diverse functions, including roles in reproduction and osmoregulation.

Purpose of the Study:

To investigate the mechanism by which ovine prolactin (oPRL) inhibits the TSH-induced increase in serum thyroxine (T4) in Fundulus heteroclitus.
To determine if oPRL affects thyroid hormone metabolism or clearance.

Main Methods:

Adult Fundulus heteroclitus were injected with oTSH and/or oPRL.
Serum T4 and T3 levels were measured.
Kinetics of 125I-labeled T4 and T3 clearance were assessed.

Related Experiment Videos

Deiodination of 125I-T4 to T3 was quantified.

Main Results:

oTSH injection increased serum T4 but not T3.
Co-administration of oPRL with oTSH blocked the TSH-induced T4 increase.
oPRL did not alter serum T3 levels.
oPRL did not affect the clearance rates of T4 or T3.
oPRL did not influence the deiodination rate of T4 to T3.

Conclusions:

oPRL prevents TSH-induced elevations in serum T4 in Fundulus heteroclitus.
The mechanism of inhibition is not due to altered thyroid hormone clearance or deiodination.
oPRL directly impacts thyroid function to modulate T4 levels.