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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
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Related Experiment Video

Updated: Jun 25, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Serological markers in fulminant hepatitis B.

A E Gimson, R S Tedder, Y S White

    Gut
    |July 1, 1983
    PubMed
    Summary

    Patients with severe hepatitis B showed lower hepatitis B surface antigen and hepatitis Be antigen levels. Enhanced antibody responses and faster antigen clearance may indicate a more severe disease course in hepatitis B infection.

    Area of Science:

    • Hepatology
    • Virology
    • Immunology

    Background:

    • Hepatitis B virus (HBV) infection is a significant global health concern.
    • Fulminant hepatic failure (FHF) represents the most severe form of acute hepatitis B.
    • Understanding serological markers associated with FHF is crucial for prognosis.

    Purpose of the Study:

    • To investigate differences in serological markers between acute hepatitis B and hepatitis B with fulminant hepatic failure.
    • To correlate specific hepatitis B virus (HBV) antigen and antibody levels with disease severity.

    Main Methods:

    • Analysis of serological markers in 34 patients with acute hepatitis B, including 17 with FHF.
    • Quantification of hepatitis B surface antigen (HBsAg) and detection of hepatitis Be antigen (HBeAg).

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    Published on: December 15, 2023

  • Measurement of IgM antibody to hepatitis B core antigen (anti-HBc IgM) and antibodies to HBsAg (anti-HBs) and HBeAg (anti-HBe).

    • Main Results:

    • Significantly lower HBsAg concentrations and less frequent HBeAg detection in FHF patients compared to acute hepatitis B patients.
    • Higher median levels of anti-HBc IgM in FHF patients (500 IU/ml) versus uncomplicated hepatitis B (202 IU/ml).
    • Detectable anti-HBs or anti-HBe in three FHF cases, suggesting robust antibody responses.

    Conclusions:

    • Lower HBsAg and HBeAg levels in FHF may indicate enhanced immune response and faster viral clearance.
    • Elevated anti-HBc IgM is associated with a more severe course of hepatitis B.
    • These serological findings suggest a complex interplay between viral load and host immune response in HBV-induced FHF.