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Related Experiment Videos

Elevated plasma carnitine in hepatic cirrhosis.

R K Fuller, C L Hoppel

    Hepatology (Baltimore, Md.)
    |July 1, 1983
    PubMed
    Summary

    Patients with alcoholic cirrhosis exhibit elevated levels of plasma carnitine and its metabolites. This study found significantly higher concentrations of total, free, short-chain, and long-chain carnitine in cirrhotic individuals compared to healthy controls.

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    Area of Science:

    • Biochemistry
    • Hepatology
    • Metabolic Disorders

    Background:

    • Carnitine is crucial for fatty acid oxidation, a key liver function.
    • Alcoholic cirrhosis significantly impacts liver function and metabolism.
    • Alterations in carnitine levels may indicate metabolic disturbances in liver disease.

    Purpose of the Study:

    • To investigate plasma carnitine and acylcarnitine levels in patients with alcoholic cirrhosis.
    • To compare carnitine profiles between cirrhotic patients and healthy volunteers.
    • To determine if alcoholic cirrhosis is associated with hypercarnitinemia.

    Main Methods:

    • Radioenzymatic assay used to measure plasma carnitine and its metabolites.
    • Study included 20 men with hepatic cirrhosis and 30 healthy control subjects.
    • Quantification of total carnitine, free carnitine, short-chain acylcarnitines, and long-chain acylcarnitines.

    Main Results:

    • Significantly elevated levels of total carnitine, free carnitine, short-chain acylcarnitines, and long-chain acylcarnitines were observed in cirrhotic patients.
    • Mean total carnitine: 73.1 µM (cirrhosis) vs. 46.1 µM (controls).
    • Mean acylcarnitines showed substantial increases: 3-fold for short-chain and over 2-fold for long-chain.

    Conclusions:

    • Alcoholic cirrhosis is characterized by elevated plasma carnitine levels, a condition termed hypercarnitinemia.
    • Acylcarnitines, particularly short-chain and long-chain forms, are markedly increased in alcoholic cirrhosis.
    • Carnitine metabolism may be significantly altered in patients with advanced liver disease.

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