Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute poisoning with ibuprofen.

H Court, P Streete, G N Volans

    Human Toxicology
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Ibuprofen overdose is generally of low toxicity, with most patients experiencing no or mild symptoms. Supportive care is recommended for acute overdose cases, as serious symptoms are rare and often not definitively linked to ibuprofen.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of food and exercise on the absorption of effervescent aspirin.

    British journal of clinical pharmacology·2012
    Same author

    The influence of thiethylperazine on the absorption of effervescent aspirin in migraine.

    British journal of clinical pharmacology·2012
    Same author

    Secobarbital poisoning in an Amur tiger (Panthera tigris altaica).

    The Veterinary record·2010
    Same author

    How effective is the new community-based Welsh low vision service?

    The British journal of ophthalmology·2010
    Same author

    What's being used to spike your drink? Alleged spiked drink cases in inner city London.

    Postgraduate medical journal·2007
    Same author

    A pharmacokinetic study of piroxicam in children.

    Anaesthesia·2004
    Same journal

    Intracellular localization of cerium. A microanalytical study using an electron microprobe and ionic microanalysis.

    Human toxicology·1989
    Same journal

    Self-poisoning in Sri Lanka: factors determining the choice of the poisoning agents.

    Human toxicology·1989
    Same journal

    The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).

    Human toxicology·1989
    Same journal

    Pharmacokinetics and toxic effects of diltiazem in massive overdose.

    Human toxicology·1989
    Same journal

    Acute renal failure following accidental cutaneous absorption of phenol: application of NMR urinalysis to monitor the disease process.

    Human toxicology·1989
    Same journal

    Toxicological data after heroin overdose.

    Human toxicology·1989
    See all related articles

    Area of Science:

    • Pharmacology
    • Toxicology
    • Emergency Medicine

    Background:

    • Acute overdose cases present a clinical challenge in assessing toxicity.
    • Understanding the toxicological profile of common analgesics like ibuprofen is crucial for patient management.

    Purpose of the Study:

    • To evaluate the toxicity and clinical outcomes of ibuprofen overdose.
    • To determine the relationship between plasma ibuprofen concentrations and symptom severity.

    Main Methods:

    • Retrospective analysis of 75 ibuprofen overdose cases over two years.
    • Detailed review of symptoms, treatment, and outcomes for available cases (64%).
    • Correlation of plasma ibuprofen levels with clinical presentation in 13 cases.

    Main Results:

    Related Experiment Videos

    • Majority of patients experienced no or mild symptoms (e.g., nausea, vomiting).
    • Three cases with severe symptoms had uncertain ibuprofen involvement.
    • High plasma ibuprofen concentrations (up to 704 mg/l) were observed in asymptomatic individuals.

    Conclusions:

    • Ibuprofen exhibits low toxicity in acute overdose scenarios.
    • Clinical management should focus on supportive care.
    • High plasma concentrations do not always correlate with severe symptoms.