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Selenium and immune functions in humans.

H Arvilommi, K Poikonen, I Jokinen

Infection and Immunity

|July 1, 1983

Summary

This study found that selenium supplementation in individuals with low selenium levels improved selenium status and enhanced granulocyte function. However, overall immune function was minimally affected by selenium deficiency in this population.

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Area of Science:

Human nutrition and immunology
Trace element research

Background:

Animal studies suggest selenium depletion impairs immune function.
Human populations in some regions have low serum selenium concentrations.

Purpose of the Study:

To investigate the impact of selenium supplementation on immune function in selenium-deficient humans.
To assess the relationship between selenium status and immune cell activity.

Main Methods:

A double-blind, placebo-controlled trial with 40 volunteers.
Supplementation with selenium or placebo for 11 weeks.
Analysis of serum selenium, glutathione peroxidase activity, and in vitro immune cell functions.

Main Results:

Selenium supplementation significantly increased plasma selenium levels and platelet glutathione peroxidase activity.

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Granulocyte intracellular killing of Staphylococcus aureus was improved in the selenium group.

No significant changes were observed in other measured immune parameters.

Conclusions:

Selenium deficiency, as observed in this study, has minimal impact on most measured immune functions.
Supplementation can improve selenium status and specific granulocyte activity.