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Related Experiment Videos

Local and systemic factors regulating mucosal mast cells.

R M Pitts, G Mayrhofer

    International Archives of Allergy and Applied Immunology
    |January 1, 1983
    PubMed
    Summary

    Local and systemic factors regulate mucosal mast cells and globule leukocytes in rats. Nippostrongylus brasiliensis infection shows these immune cells respond without direct parasite contact, challenging prior understanding.

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    Area of Science:

    • Immunology
    • Parasitology
    • Gastroenterology

    Background:

    • Mucosal mast cells and globule leukocytes are key immune cells in the gut.
    • Their regulation by local and systemic factors is not fully understood.
    • Nippostrongylus brasiliensis infection is a known stimulus for mast cell hyperplasia.

    Purpose of the Study:

    • To investigate the roles of local and systemic factors in regulating mucosal mast cells and globule leukocytes.
    • To determine the necessity of intestinal vs. extraintestinal sensitization for immune responses.
    • To examine the impact of parasite contact on mast cell hyperplasia.

    Main Methods:

    • Used the Nippostrongylus brasiliensis model in rats.
    • Compared gut mast cell responses to larval and adult worm infestations.
    • Examined systemic effects using isolated Thiry-Vella intestinal loops.

    Main Results:

    • Extraintestinal larval infestation is not essential for gut mast cell response.
    • Mast cell hyperplasia and globule leukocyte formation occur independently of direct parasite contact.
    • Systemic factors influence immune responses in isolated intestinal segments.

    Conclusions:

    • Gut mast cell responses can be initiated without direct parasite contact or extraintestinal larval stages.
    • Both local and systemic factors contribute to the regulation of mucosal immune cells.
    • Findings provide new insights into the dissemination and significance of mast cell responses in parasitic infections.

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