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A comparison of a disposable membrane filtration system with a direct inoculation system for the sterility testing of
Journal of Biological Standardization
|April 1, 1983
Abstract:
A direct inoculation method for sterility testing veterinary biologics was compared with a closed membrane filtration method (Steritest). The filtration method detected extraneous contamination in 29% more batches of biologics than the direct inoculation method. Live viral biologics produced in cell culture were found to be the only product type that could be filtered; hence the filtration method cannot be recommended universally as a replacement for the direct inoculation method.