Related Experiment Videos
The morphogenesis of a papillomatous gastric polyp in the crab-eating monkey (Macaca fascicularis)
Abstract:
The histopathology of gastric papillomas in 17 crab-eating monkeys from Indonesia and Malaysia was investigated. The changes in the affected mucosa consisted of papillomatous proliferation with accidental heterotopia, desquamation or necrosis of the epithelium associated with eggs or adults of the small nematode Nochtia nochti, inflammatory cell infiltration and haemorrhage or oedema and fibrosis. The primary pathogenic effect of this parasite was due to its irritant action on the gastric mucosa. Hyper-regeneration, with a downward shift of the proliferating zone in the gastric gland and an inflammatory process, appeared to play a significant role in the morphogenesis of this lesion. It is concluded that the gastric papilloma associated with Nochtia nochti in the monkey is a parasitic inflammatory polyp.
Insights
Gastric papillomas in monkeys are caused by the nematode Nochtia nochti. This parasitic infection leads to inflammation and tissue changes, forming a parasitic inflammatory polyp.
Area of Science:
- Veterinary Pathology
- Parasitology
- Gastroenterology
Background:
- Gastric papillomas are observed in crab-eating monkeys.
- The nematode Nochtia nochti is implicated in gastric lesions.
Purpose of the Study:
- To investigate the histopathology of gastric papillomas in crab-eating monkeys.
- To understand the role of Nochtia nochti in lesion development.
Main Methods:
- Histopathological examination of gastric tissues from 17 monkeys.
- Identification and analysis of nematode presence and associated mucosal changes.
Main Results:
- Gastric papillomas showed papillomatous proliferation, epithelial changes (desquamation, necrosis), and inflammatory infiltration.
- Lesions were associated with eggs or adults of Nochtia nochti.
- Parasite's irritant action, hyper-regeneration, and inflammation were key in lesion morphogenesis.
Conclusions:
- The gastric papilloma associated with Nochtia nochti is a parasitic inflammatory polyp.
- The nematode's irritant action is the primary pathogenic effect.
- Inflammatory and regenerative processes are significant in the development of these polyps.