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Related Experiment Videos

Methotrexate-induced necrolysis.

K M Reed, A J Sober

    Journal of the American Academy of Dermatology
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Methotrexate, a folic acid antagonist, can cause severe skin reactions like toxic epidermal necrolysis in patients with psoriasis. Underlying skin conditions may increase susceptibility to these adverse drug reactions.

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    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Methotrexate is a folic acid antagonist used in treating psoriasis.
    • Adverse drug reactions can occur with methotrexate therapy.

    Observation:

    • A 72-year-old woman with recalcitrant psoriasis developed severe generalized erosions.
    • The patient received a low dose of methotrexate (7.5 mg).
    • The clinical presentation was consistent with toxic epidermal necrolysis.

    Findings:

    • Severe generalized erosions developed post-methotrexate initiation.
    • The patient showed a gradual response to systemic steroids and topical treatments.
    • Underlying dermatoses may predispose patients to adverse cutaneous reactions from folic acid antagonists.

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    Implications:

    • Clinicians should be aware of the potential for severe skin reactions with methotrexate, even at low doses.
    • Patients with pre-existing skin conditions may require careful monitoring during methotrexate therapy.
    • This case highlights the importance of considering drug-induced toxic epidermal necrolysis in patients with psoriasis presenting with severe erosions.