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Acute hepatitis associated with campylobacter colitis.

K R Reddy, J B Farnum, E Thomas

    Journal of Clinical Gastroenterology
    |June 1, 1983
    PubMed
    Summary
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    Campylobacter fetus ss. jejuni infection can cause acute colitis and temporary liver dysfunction. This case shows complete recovery after treatment for the bacterial infection.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Campylobacter fetus subspecies jejuni is a common cause of bacterial gastroenteritis.
    • Hepatocellular dysfunction is not a typical presentation of Campylobacter infections.

    Observation:

    • A patient presented with acute colitis confirmed as Campylobacter fetus ss. jejuni infection.
    • The patient subsequently developed hepatocellular dysfunction that mirrored the colitis severity.
    • Liver biopsy revealed nonspecific reactive hepatitis, with other causes of liver damage ruled out.

    Findings:

    • The hepatocellular dysfunction resolved completely as the colitis was treated.
    • This suggests a direct or indirect link between Campylobacter colitis and transient liver injury.

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    Implications:

    • Campylobacter infections should be considered in the differential diagnosis of acute liver injury, especially in the context of colitis.
    • Further research may elucidate the mechanisms of Campylobacter-associated hepatitis.