A clinicopathological study on glandular cystic hyperplasia of the endometrium

Biopsy specimens of the endometrium obtained from the 154 cases diagnosed as glandular cystic hyperplasia were classified into 3 types. The results obtained are as follows: 1) The number of cases thus classified was 43 for type I, 78 for type II and 33 for type III. 2) Clinical diagnosis showed that functional uterine bleeding had the highest incidence, followed by myoma of the uterus, endometrial carcinoma and abortion in this order. 3) By age, 69.0% of the cases was concentrated in the fifth decade, the average age being 44.7 years. 4) Major clinical symptoms were 1) irregular cycle of menstruation, 2) prolonged genital bleeding, 3) anemia and 4) recurrence of symptoms. These symptoms were observed most frequently in type I, followed by type II and type III. Similar tendency was observed also in the incidence of complications with some of these symptoms. 5) The degree of endometrial hypertrophy was 3.7 +/- 1.0 mm for type I, 2.8 +/- 0.9 mm for type II and 1.6 +/- 0.9 mm for type III. 6) The incidence of the endometrial glandular epithelium in its active form was 70.7% for type I, 26.7% for type II and 25.9% for type III. 7) Stromal hyperplasia was found in 70.7% of the type I, 50.0% of the type II and 29.6% of the type III respectively.