Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal function during lactation in the rat.

S K Arthur, R Green

    The Journal of Physiology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Lactation significantly increases glomerular filtration rate (g.f.r.) and renal plasma flow (r.p.f.) in rats, but these renal function changes normalize before plasma prolactin and progesterone levels do.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The psychology of human error.

    European journal of anaesthesiology·1999
    Same author

    Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week.

    The Journal of allergy and clinical immunology·1999
    Same author

    Reflections of thrombosis research in Oklahoma City--1975 to the present.

    The Journal of the Oklahoma State Medical Association·1999
    Same author

    Reconstitution of functional 50S ribosomes from in vitro transcripts of Bacillus stearothermophilus 23S rRNA.

    Biochemistry·1999
    Same author

    The effect of continuous drug exposure on the immune response to Trichostrongylus colubriformis in sheep.

    Veterinary parasitology·1999
    Same author

    Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status.

    Seminars in hematology·1999
    Same journal

    Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex.

    The Journal of physiology·2026
    Same journal

    Fasting-induced glucose intolerance is not impacted by the addition of daily exercise: A randomized crossover study.

    The Journal of physiology·2026
    Same journal

    Diving exposure and pulmonary stress.

    The Journal of physiology·2026
    Same journal

    Systems modelling of mitochondrial dynamics in different exercise regimes.

    The Journal of physiology·2026
    Same journal

    Central leptin resistance precedes obesity and drives early endocrine dysfunction.

    The Journal of physiology·2026
    Same journal

    Decoding the molecular memory of obesity using machine learning and microRNA dynamics.

    The Journal of physiology·2026
    See all related articles

    Area of Science:

    • Physiology
    • Reproductive Biology
    • Nephrology

    Background:

    • Renal function undergoes significant adaptations during pregnancy and lactation.
    • Hormonal changes, particularly involving prolactin and progesterone, are known to influence these adaptations.
    • The precise interplay between hormonal shifts and renal hemodynamics during lactation requires further elucidation.

    Purpose of the Study:

    • To investigate the dynamic changes in glomerular filtration rate (g.f.r.), renal plasma flow (r.p.f.), and salt/water reabsorption during lactation in rats.
    • To correlate these renal functional changes with plasma concentrations of progesterone and prolactin.
    • To identify the primary drivers of renal adaptation during lactation.

    Main Methods:

    • Measurements of g.f.r., r.p.f., salt and water reabsorption in virgin, 19-day pregnant, and lactating rats.

    Related Experiment Videos

  • Quantification of plasma progesterone and prolactin levels using validated assays.
  • Comparative analysis of renal parameters across different physiological states.

    • Main Results:

    • Glomerular filtration rate (g.f.r.) increased by approximately 40% during early lactation (6-7 days) compared to virgin rats, returning to baseline by late lactation.
    • Renal plasma flow (r.p.f.) rose by about 30% during peak lactation, leading to a 10% increase in filtration fraction.
    • Plasma prolactin and progesterone levels remained elevated even after renal function returned to normal virgin levels.

    Conclusions:

    • Renal function, including g.f.r. and r.p.f., undergoes significant, transient increases during lactation in rats.
    • Elevated prolactin and progesterone concentrations alone do not fully explain the observed lactation-induced renal adaptations.
    • Non-hormonal factors likely play a crucial role in modulating renal hemodynamics during the postpartum period.