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The failure of oxygen breathing to decrease the myocardial contractile force in denervated dogs.

K Ishikawa, K Kanamasa, T Yamakado

    Japanese Circulation Journal
    |July 1, 1983
    PubMed
    Summary
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    Oxygen breathing reduces myocardial contractile force in intact dogs, but not in denervated dogs. This indicates that sympathoadrenal activity mediates this oxygen-induced depression, impacting heart function.

    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Oxygen breathing can affect cardiac function.
    • The role of sympathoadrenal activity in oxygen-induced cardiac depression is not fully understood.

    Purpose of the Study:

    • To investigate if oxygen-induced depression of sympathoadrenal activity contributes to reduced myocardial contractile force during oxygen breathing.

    Main Methods:

    • Myocardial contractile force was measured in open-chest dogs under both intact and denervated conditions.
    • Dogs underwent air and 100% oxygen breathing.
    • Pharmacological blockade of the sympathoadrenal system was performed.

    Main Results:

    • Oxygen breathing significantly reduced myocardial contractile force in intact dogs.

    Related Experiment Videos

  • No significant changes in myocardial contractile force were observed in denervated dogs.
  • Coronary blood flow decreased during oxygen breathing in both groups.

    • Conclusions:

    • Oxygen-induced reduction in myocardial contractile force is mediated by sympathoadrenal activity.
    • Sympathoadrenal blockade abolishes the negative impact of oxygen on myocardial contractile force.