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Related Experiment Videos

[Tryptophan loading test as a function parameter in liver diseases].

M Rössle, R Herz, W Hiss

    Klinische Wochenschrift
    |March 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    The oral tryptophan loading test effectively assesses liver function in chronic liver disease patients. Prolonged tryptophan half-life indicates impaired hepatic function and may predict hepatic encephalopathy risk.

    Area of Science:

    • Hepatology
    • Clinical Biochemistry
    • Pharmacokinetics

    Background:

    • Chronic liver diseases significantly impair hepatic function.
    • Assessing liver function requires reliable and specific diagnostic tests.
    • Tryptophan undergoes specific degradation in the liver, making it a potential biomarker.

    Purpose of the Study:

    • To evaluate the efficacy of an oral tryptophan loading test for assessing hepatic function in patients with chronic liver diseases.
    • To determine the correlation between tryptophan half-life and established markers of liver function.
    • To explore the utility of the tryptophan test in predicting hepatic encephalopathy.

    Main Methods:

    • Oral administration of tryptophan (50 mg/kg) to patients with chronic liver diseases (n=30) and healthy volunteers (n=8).

    Related Experiment Videos

  • Measurement of plasma tryptophan half-life (t½) at 4-8 hours post-administration.
  • Correlation analysis with liver function tests (albumin, bilirubin, cholinesterase, prothrombin time), galactose elimination capacity, and BSP retention.

    • Main Results:

    • Tryptophan half-life was significantly prolonged in cirrhotic patients (4.7 ± 0.4 h) compared to controls (2.0 ± 0.1 h).
    • Tryptophan half-life correlated significantly with albumin, bilirubin, cholinesterase, prothrombin time, galactose elimination capacity, and BSP retention.
    • In decompensated cirrhotic patients, altered tryptophan metabolism correlated with indicators of hepatic encephalopathy.

    Conclusions:

    • The oral tryptophan loading test is a suitable method for specifically determining functional impairment in chronic liver disease.
    • The test may serve as a valuable tool for assessing the degree and risk of hepatic encephalopathy.