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Dermatitis in nude mice (nu/nu) associated with Staphylococcus pyogenes
Laboratory Animals
|January 1, 1983
Summary
Nude mice over 10 weeks old developed Staphylococcus pyogenes-induced moist dermatitis. Antibiotic treatments including ampicillin and oxytetracycline proved ineffective in resolving the skin condition and associated infections.
Area of Science:
- Immunology
- Microbiology
- Dermatology
Background:
- Nude mice (nu/nu BALB/cAn) are commonly used in research.
- These mice, under conventional conditions, can be susceptible to opportunistic infections.
- Staphylococcus pyogenes is a known bacterial pathogen.
Purpose of the Study:
- To describe a spontaneous skin condition in nude mice.
- To identify the causative agent of the dermatitis.
- To evaluate the efficacy of common antibiotic treatments.
Main Methods:
- Observation of clinical signs in nude mice.
- Bacteriological culture to identify microbial contaminants.
- Age and genetic status (homozygotes) correlation with disease.
- Assessment of treatment response to ampicillin and oxytetracycline.
Main Results:
- Acute moist dermatitis of the nose and ears occurred in nude mice over 10 weeks old.
- Heavy contamination with Staphylococcus pyogenes was confirmed.
- Conjunctivitis and periorbital abscesses were also observed.
- Parenteral ampicillin and oral oxytetracycline treatments were ineffective.
Conclusions:
- Nude mice over 10 weeks old are susceptible to Staphylococcus pyogenes-induced dermatitis.
- Standard antibiotic therapies may not be effective for this specific condition in this model.
- Further investigation into treatment strategies for Staphylococcus pyogenes infections in immunocompromised models is warranted.