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Related Experiment Videos

Hydronephrosis in the inbred mouse strain DDD.

Y Nakajima, K Imamura, T Onodera

    Laboratory Animals
    |April 1, 1983
    PubMed
    Summary

    The DDD mouse strain exhibits a high incidence of hydronephrosis, a kidney condition. This strain serves as a valuable model for studying renal hemodynamics and function.

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    Area of Science:

    • Nephrology
    • Animal Models
    • Genetics

    Background:

    • Hydronephrosis is a condition characterized by kidney swelling due to urine backup.
    • Inbred mouse strains are frequently used to study genetic predispositions to diseases.
    • The DDD mouse strain's genetic makeup is largely unknown regarding renal pathologies.

    Purpose of the Study:

    • To characterize the incidence and features of hydronephrosis in the DDD mouse strain.
    • To evaluate the potential of DDD mice as a model for renal hemodynamic and functional studies.

    Main Methods:

    • Phenotypic assessment of hydronephrosis in adult male and female DDD mice.
    • Classification of hydronephrosis based on obstruction and laterality.
    • Observation of associated renal pathologies, including circulatory failure.

    Main Results:

    • An extremely high incidence of hydronephrosis was observed in DDD mice (37/37 males, 12/32 females).
    • The hydronephrosis was predominantly open, lacking a clear obstructive cause.
    • The condition presented as unilateral (right kidney) or bilateral, often accompanied by circulatory failure.

    Conclusions:

    • The DDD mouse strain is a highly relevant model for hydronephrosis research.
    • This model offers opportunities to investigate disturbances in renal hemodynamics and function.
    • Further research is warranted to elucidate the genetic and mechanistic basis of hydronephrosis in DDD mice.

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