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Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
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Interstitial pneumonia from mitomycin

E S Orwoll, P J Kiessling, J R Patterson

    Annals of Internal Medicine
    |September 1, 1978
    PubMed

    Insights

    Mitomycin (Mutamycin) therapy can cause interstitial pneumonia, a rare pulmonary disease. Early corticosteroid treatment offers a rapid and effective response in affected patients.

    Area of Science:

    • Oncology
    • Pulmonology
    • Pharmacology

    Background:

    • Chemotherapeutic agents are known to cause pulmonary disease.
    • Mitomycin (Mutamycin) is an alkylating agent used in chemotherapy.
    • Pulmonary complications associated with mitomycin have not been previously documented.

    Observation:

    • Three patients receiving mitomycin therapy developed interstitial pneumonia.
    • Clinical symptoms included dyspnea, cough, and fever.
    • Chest roentgenograms revealed reticular infiltrates.

    Findings:

    • Histological examination showed diffuse alveolar septal edema.
    • Mononuclear-cell interstitial infiltrates and alveolar lining cell hypertrophy were observed.
    • Alveolar septal collagen deposition was a characteristic finding.

    Implications:

    • This study identifies interstitial pneumonia as a potential adverse effect of mitomycin.
    • Prompt corticosteroid treatment appears effective in managing mitomycin-induced interstitial pneumonia.
    • Further research is warranted to understand the mechanism and incidence of this pulmonary toxicity.

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