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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
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Published on: November 7, 2018

Aprindine hepatitis.

H F Herlong, P R Reid, J K Boitnott

    Annals of Internal Medicine
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Aprindine, an antiarrhythmic drug, can cause hepatitis in patients. Symptoms appeared within 3 weeks and resolved upon drug withdrawal, with one patient experiencing recurrence after reintroduction.

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    Area of Science:

    • Pharmacology
    • Hepatology
    • Internal Medicine

    Background:

    • Antiarrhythmic agents are crucial for managing cardiac arrhythmias.
    • Aprindine is a novel antiarrhythmic medication.
    • Drug-induced liver injury is a significant concern in clinical practice.

    Observation:

    • Two patients developed hepatitis following aprindine administration.
    • Hepatitis symptoms manifested within three weeks of starting aprindine therapy.
    • Cessation of aprindine led to rapid resolution of hepatitis in both cases.

    Findings:

    • Aprindine is identified as the causative agent for hepatitis in these patients.
    • Drug-induced hepatitis resolved upon discontinuation of aprindine.
    • One patient experienced recurrent hepatitis upon aprindine re-challenge, which later resolved despite continued drug use.

    Implications:

    • Clinicians should consider aprindine as a potential cause of hepatitis.
    • Monitoring liver function is essential for patients on aprindine therapy.
    • Further research into the hepatotoxicity of aprindine is warranted.